منابع مشابه
(+)-Geodin from Aspergillus terreus.
The fungal metabolite (+)-geodin [systematic name: (2R)-methyl 5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2,1'-cyclohexa-2',5'-diene]-2'-carboxylate], C(17)H(12)Cl(2)O(7), was isolated from Aspergillus terreus. The crystal structure contains two independent molecules in the asymmetric unit. Molecules denoted 1 interact through O-H...O hydrogen bonds creating chains of...
متن کاملButyrolactones from Aspergillus terreus.
In the process development of lovastatin using Aspergillus terreus DRCC 152 in solid state fermentation, we have isolated a new butyrolactone-IV (3) along with the previously reported butyrolactone-I (1) and butyrolactone-II (2) produced under submerged conditions. The structure of compound 3 has been characterized as 3-hydroxy-5-[2-(1-hydroxy-1-methylethyl)-2(R)-2,3-dihydro-benzo[b]furan- 5 yl...
متن کاملLxxi. Studies in the Biochemistry of Micro-organisms Lxi. the Molecular Constitution of Geodin and Erdin, Two Chlorine-containing Meta- Bolic Products of Aspergillus Terreus Thom. Part Ii. Dihydrogeodin and Dihydroerdin and the Synthesis of Their Trimethyl Ethers
RAISTRICK & SMITH [1936] showed that a strain of Aspergillu8 terreus Thomr, when grown on Czapek-Dox solution containing glucose as sole source of carbon and KCI as sole source of chlorine, produced two new metabolic products, geodin,. C15H605C12(0CH3)2, and erdin, C15H706C12(OCH3), each of which on catalytic reduction gave rise to a dihydro-derivative. Later, Clutterbuck et al. [1937] found th...
متن کاملHeterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach
Fungal natural products are a rich resource for bioactive molecules. To fully exploit this potential it is necessary to link genes to metabolites. Genetic information for numerous putative biosynthetic pathways has become available in recent years through genome sequencing. However, the lack of solid methodology for genetic manipulation of most species severely hampers pathway characterization....
متن کاملMicrobial transformation of artemisinin by Aspergillus terreus
BACKGROUND Artemisinin (1) and its derivatives are now being widely used as antimalarial drugs, and they also exhibited good antitumor activities. So there has been much interest in the structural modification of artemisinin and its derivatives because of their effective bioactivities. The microbial transformation is a promising route to obtain artemisinin derivatives. The present study focuses...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section C Crystal Structure Communications
سال: 2011
ISSN: 0108-2701
DOI: 10.1107/s0108270111005816